Table of contents
Orthologs are found in mammals and birds. The TLR family plays an important role in pathogen recognition and activation of innate immunity.
TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns PAMPs that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung , placenta , and spleen , and lies in close proximity to another family member, TLR8 , on the human X chromosome.
TLR7 recognizes single-stranded RNA in endosomes , which is a common feature of viral genomes which are internalised by macrophages and dendritic cells.
TLRs and Innate Immunity
Imiquimod acts upon TLR7. TLR7 has been shown to play a significant role in the pathogenesis of autoimmune disorders such as Systemic Lupus Erythematosus SLE as well as in the regulation of antiviral immunity.
Due to their ability to induce robust production of anti-cancer cytokines such as interleukin , TLR7 agonists have been investigated for cancer immunotherapy.
Recent examples include TMX delivery via liposomal formulation,  as well as the delivery of resiquimod via nanoparticles formed from beta-cyclodextrin. From Wikipedia, the free encyclopedia.
About this book
X chromosome human . National Center for Biotechnology Information, U.
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TLR Genes and Expression
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Mini-review: Toll-like Receptors (TLRs)
Gene location Human. Gene location Mouse. X chromosome mouse . RNA expression pattern.
Immunology - Toll Like Receptors Overview
More reference expression data. Chr X: You can help Wikipedia by expanding it.