Artificial Sweetening Agents Pdf Merge

Artificial sweetening agents pdf merge

This application claims the U.

Present invention relates in general to steviol glycoside, together with the composition comprising this type of steviol glycoside. The present invention extend to further preparation and this type of steviol glycoside of purifying method, for the preparation of comprise this type of steviol glycoside composition such as, the consumer's goods method and for using steviol glycoside and comprising the composition enhancing local flavor of the consumer's goods or the method for sugariness of steviol glycoside.

Especially, sucrose imparts the taste for human consumer has a preference for. Although sucrose provides superior sugariness feature, it has heat. Empty calory or sweeting agent low in calories are introduced to meet consumer demand. But the sweeting agent in this type of is to continue to obstruct the mode of human consumer to be different from the sugar of natural heat type. Based on source, many empty calories or sweeting agent low in calories are the chemical of synthesis.

Very high to the still hope of the natural empty calory or sweeting agent low in calories of tasting picture sucrose. Sweet Stevia SteviarebaudianaBertoni is perennial Aster tataricus section Asteraceae composite family the Compositae shrub of spontaneous growth certain areas in South America.

Its leaf has employed tea and the medicine of sweet taste locality for hundreds of years traditionally in Paraguay and Brazil. These diterpene glycosides are sweeter than sugar about to times.

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In structure, the feature of diterpene glycosides is single base, steviol, and difference is to there is carbohydrate residue in C13 and C19 position. Typically, based on dry weight, four kinds that find in the leaf of sweet Stevia main steviol glycosides are Du Ke glycosides A 0. Other glucosides identified in qualities of stevia extract comprise Lay bud enlightening glycosides B, D, E and F, steviolbioside and Rubusoside. In these, only stevioside and Lay bud enlightening glycosides A are operational at commercial size.

The use of steviol glycoside so far by some undesirable taste characteristic comprising the taste of Radix Glycyrrhizae, bitter taste, astringent taste, sweet pleasant impression, bitter pleasant impression, Radix Glycyrrhizae pleasant impression restriction, and becomes more remarkable with the increase of concentration.

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The use of this level causes the remarkable deterioration of the taste of the finished product. Therefore, for the natural reduction heat of exploitation or the sweeting agent of empty calory still there are a kind of needs, this sweeting agent provides the time and flavor characteristic that are similar to sucrose. Further needs are still existed for the method from sweet Stevia purifying steviol glycoside.

Artificial sweetening agents pdf merge

Present invention relates in general to steviol glycoside and comprise the composition of this type of steviol glycoside, together with preparation and the method for this type of steviol glycoside of purifying, preparation comprise the composition such as, the consumer's goods of this type of steviol glycoside method and for using these steviol glycosides and composition to strengthen the local flavor of the consumer's goods or the method for sugariness.

In an aspect, the present invention is the steviol glycoside that one has formula 1 :. R is the heteroaryl of alkyl, the alkyl of replacement, thiazolinyl, the thiazolinyl of replacement, alkynyl, the alkynyl of replacement, the aryl of replacement, heteroaryl, replacement, and maybe when being attached on a nitrogen-atoms, two adjacent R group can combine to form 5 to 7 rings;.

Artificial sweetening agents pdf merge

Wherein when x is a singly-bound, R 2 and R 3 form a carbonyl or alkene as a whole;. Wherein when x is a double bond, or R 2 or R 3 non-existent; And.

Wherein, R 2 and R 3 be independently selected from lower group, this group is made up of the following: hydrogen; Hydroxyl; Hydroxyalkyl; Halogen; Amino, sulfydryl, cyano group, C1-C6 straight chained alkyl, C1-C6 branched-chain alkyl, C2-C6 thiazolinyl, C3-C8 cycloalkyl, heterocycle, heteroaryl and aryl; C1-C6 alkoxyl group; Aryl; Heteroaryl; Heterocycle, wherein all one or more replacements that optionally can be independently selected from lower group, this group is made up of the following: halogen, alkyl, low alkyl group, acyl group, oxo base oxo , hydroxyl, hydroxyalkyl, alkoxyl group, heterocycle, heteroaryl, cyano group, amino, aminoalkyl group and carboxyl;.

In one more specifically embodiment, x is a singly-bound and R 2 and R 3 form a kind of alkene or a carbonyl as a whole. In another specific embodiment, x is a singly-bound and R 2 and R 3 be selected from C1-C6 straight chained alkyl and hydroxyl. In another specific embodiment, R 1 and R 4 be selected from hydrogen independently of one another, oligose that methyl is connected with a kind of O-, wherein this oligose comprises the sugar from two to five.

In other embodiments, R 1 and R 4 a kind of oligose comprising monose independently of one another, this monose is selected from but is not limited to lower group, this group is made up of the following: Glycerose, otan, erythrose, threose, erythrulose, pectinose, lyxose, ribose, wood sugar, ribulose, xylulose, allose, altrose, semi-lactosi, glucose, gulose, idose, seminose, talose, fructose, psicose, sorbose, tagatose, mannoheptulose, sedoheptulose sedoheltulose , octulose, Fucose, rhamnosyl, pectinose, turanose and sialic saccharide sialose.

In one more specifically embodiment, the present invention is a kind of steviol glycoside, this steviol glycoside is selected from lower group, and this group is made up of the following: 1a , 1b , 1c , 1d , 1e , 1f and 1g :.

In another embodiment, the present invention is the steviol glycoside that one has formula 2 :. Wherein R 1 , R 2 , R 3 , and R 4 keep as defined above. In other embodiments, R 1 and R 4 a kind of oligose comprising monose independently of one another, this monose is selected from but is not limited to lower group, and this group is made up of the following: Glycerose, otan, erythrose, threose, erythrulose, pectinose, lyxose, ribose, wood sugar, ribulose, xylulose, allose, altrose, semi-lactosi, glucose, gulose, idose, seminose, talose, fructose, psicose, sorbose, tagatose, mannoheptulose, sedoheptulose, octulose, Fucose, rhamnosyl, pectinose, turanose and sialic saccharide.

Artificial sweetening agents pdf merge

In embodiment more specifically, the present invention is a kind of steviol glycoside, and this steviol glycoside is selected from 2a , 2b , 2c , 2d , 2e , 2f and 2g :.

Steviol glycoside 2f is also referred to as Lay bud enlightening glycosides N and steviol glycoside 2g is also referred to as Lay bud enlightening glycosides O. In one aspect of the method, the present invention is the composition that one comprises the compound with formula 1.

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In one embodiment, the present invention is the sweetener composition that one comprises the compound with formula 1. In another embodiment, the present invention is a kind of local flavor enhancing composition, this local flavor enhancing composition comprises the compound that one has formula 1 , wherein when this local flavor enhancing composition being added in a kind of consumer's goods, this compound with formula 1 effectively provides to be in or to exist lower than this amount with the concentration of the threshold value local flavor identification level of the compound of formula 1.

In a specific embodiment, when this local flavor enhancing composition being added in a kind of consumer's goods, this compound with formula 1 effectively provides the amount having the concentration of the threshold value local flavor identification level of the compound of formula 1 lower than this to exist.

In another embodiment again, the present invention is a kind of sugariness enhancing composition, this sugariness enhancing composition comprises the compound that one has formula 1 , wherein when this sugariness enhancing composition being added in a kind of consumer's goods, this compound with formula 1 effectively provides to be in or to exist lower than this amount with the concentration of the threshold value sugariness identification level of the compound of formula 1.

In a specific embodiment, when this sugariness enhancing composition being added in a kind of consumer's goods, this compound with formula 1 effectively provides the amount having the concentration of the threshold value sugariness identification level of the compound of formula 1 lower than this to exist.

In another embodiment again, the present invention is the consumer's goods that one comprises the compound with formula 1. The suitable consumer's goods include, but not limited to based on liquid or the consumer's goods of drying, such as, pharmaceutical composition, edible gel mixture and composition, dental composition, food, beverage and drink product.

In a specific embodiment, the present invention is the beverage that one comprises the compound with formula 1. In a specific embodiment, this compound with formula 1 be with higher than, be in or be present in this beverage lower than this concentration with the threshold value sugariness identification concentration of the compound of formula 1.

In another specific embodiment, the present invention is a kind of drink product comprising the compound with formula 1. In a specific embodiment, this compound with formula 1 be with higher than, be in or be present in this drink product lower than this concentration with the threshold value local flavor identification concentration of the compound of formula 1. In another embodiment, this compound with formula 1 makes the sugariness of these consumer's goods enhance at least about 2.

In another embodiment, this compound with formula 1 makes the sugariness of these consumer's goods enhance from about 2. In another embodiment, this compound with formula 2 makes the sugariness of these consumer's goods enhance at least about 2.

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In another embodiment, this compound with formula 2 makes the sugariness of these consumer's goods enhance from about 2. In one embodiment, compound 2f makes the sugariness of these consumer's goods enhance from about 2. In another embodiment, compound 2g makes the sugariness of these consumer's goods enhance about 2. This at least one sweeting agent can be any sweeting agent having heat, as carbohydrate sweetening agents.

Also rare sugar can be used. In certain embodiments, composition of the present invention comprises one or more additional steviol glycosides, wherein these additional steviol glycosides are selected from lower group, and this group is made up of the following: the by product of the another kind of abstraction and purification process of commercially available qualities of stevia extract, the steviol glycoside prepared from the vegetable material such as leaf of stevioside plant, steviol glycoside, stevioside, Lay bud enlightening glycosides A, Lay bud enlightening glycosides C, Du Ke glycosides A, Rubusoside, steviolbioside, Lay bud enlightening glycosides B, Lay bud enlightening glycosides D, Lay bud enlightening glycosides F and their combination.

In other embodiments, composition of the present invention comprises one or more sweeting agents or additional sweeting agent. In one embodiment, this additional sweeting agent is a kind of natural sweeteners or synthetic sweetener.

In a specific embodiment, this additional sweeting agent is a kind of high intensity sweetner. In a specific embodiment, this additional sweeting agent is a kind of steviol glycoside. In certain embodiments, composition of the present invention comprises one or more additives.

In certain embodiments, composition of the present invention comprises one or more functional ingredient.

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In a specific embodiment, this functional ingredient is selected from lower group, and this group is made up of the following: saponin e, antioxidant, dietary fiber sources, lipid acid, VITAMIN, glycosamine, mineral substance, sanitas, hydrating agents, probiotic bacterium, prebiotics, Weight management agent, osteoporosis management agent, phytoestrogen, the saturated primary alconol of long-chain fat race, plant sterol and its combination.

In certain aspects, the present invention is the method that one prepares the compound with formula 1 , the method comprises i makes a kind of solution comprising Lay bud enlightening glycosides X contact with a kind of mineral acid, and ii heats this solution and continue time enough with the compound providing one and have formula 1 and iii reclaims the compound that this has formula 1 from this solution.

In one aspect of the method, the present invention is a kind of method that purifying has the compound of formula 1 , and the method comprises 1 makes a kind of solution comprising steviol glycoside by HPLC column and ii wash-out comprises the part that one has the compound of formula 1. These parts can carry out wash-out by adding a kind of suitable elutriant.

This elutriant can be the combination of any suitable solvent or solvent. The method can optionally comprise additional step, to have the enriched material of the compound of formula 1 as removed solvent from the solution of this wash-out to provide one to comprise. In one aspect of the method, the present invention is a kind of method for the preparation of the consumer's goods, and the method comprises i provides a kind of consumer product base and the compound that one is had formula 1 by ii adds in this consumer product base to provide a kind of consumer's goods.

In a specific embodiment, this compound with formula 1 be with higher than, be in or be present in these consumer's goods lower than this concentration with the threshold value sugariness identification of the compound of formula 1. In another specific embodiment, this compound with formula 1 be with higher than, be in or be present in these consumer's goods lower than this concentration with the threshold value local flavor identification of the compound of formula 1.

In a specific embodiment, the present invention is a kind of method for the preparation of beverage, and the method comprises i provides a kind of beverage base and the compound that one is had formula 1 by ii adds in this beverage base to provide a kind of consumer's goods.

Artificial sweetening agents pdf merge

In another specific embodiment, this compound with formula 1 be with higher than, be in or be present in these consumer's goods lower than this concentration with the threshold value local flavor identification concentration of the compound of formula 1.

In an aspect, the invention provides the steviol glycoside compound with formula 1 :. Wherein R 2 and R 3 be independently selected from lower group, this group is made up of the following: hydrogen; Hydroxyl; Hydroxyalkyl; Halogen; Amino, sulfydryl, cyano group, C1-C6 straight chained alkyl, C1-C6 branched-chain alkyl, C2-C6 thiazolinyl, C3-C8 cycloalkyl, heterocycle, heteroaryl and aryl; C1-C6 alkoxyl group; Aryl; Heteroaryl; Heterocycle, wherein all one or more replacements that optionally can be independently selected from lower group, this group is made up of the following: halogen, alkyl, low alkyl group, acyl group, oxo base, hydroxyl, hydroxyalkyl, alkoxyl group, heterocycle, heteroaryl, cyano group, amino, aminoalkyl group and carboxyl;.

In one embodiment, x is a singly-bound and R 2 and R 3 a kind of alkene as a whole. In a specific embodiment, x is a singly-bound and R 2 and R 3 a carbonyl as a whole. In another embodiment, x is a singly-bound, R 2 be a methyl and R 3 it is a hydroxyl. In certain embodiments, R 1 it is the oligose that a kind of O-connects. In the particular embodiment, R 1 be the oligose that a kind of O-comprising monose connects, these monose include, but not limited to glucose, 6-deoxidation-glucose and their combination.

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In other embodiments, R 1 it is the oligose of a kind of side chain, O-connection. Going back in other embodiments, R 1 it is the oligose of a kind of straight chain, O-connection. In certain embodiments, R 4 it is the oligose that a kind of O-connects. In the particular embodiment, R 4 be the oligose that a kind of O-comprising monose connects, these monose include, but are not limited to, glucose, rhamnosyl, wood sugar and their combination.

In other embodiments, R 4 it is the oligose of a kind of side chain, O-connection. Going back in other embodiments, R 4 it is the oligose of a kind of straight chain, O-connection. In certain embodiments, R 1 and R 4 be independently selected from monose, comprise two sugared oligose, comprise three sugared oligose, comprise four sugared oligose and comprise five sugared oligose. In certain embodiments, R 1 it is a kind of oligose, be selected from but be not limited to lower group, this group is made up of the following: Glycerose, otan, erythrose, threose, erythrulose, pectinose, lyxose, ribose, wood sugar, ribulose, xylulose, allose, altrose, semi-lactosi, glucose, gulose, idose, seminose, talose, fructose, psicose, sorbose, tagatose, mannoheptulose, sedoheptulose, octulose, Fucose, rhamnosyl, pectinose, turanose and sialic saccharide.

In certain embodiments, R 4 it is a kind of oligose, be selected from but be not limited to lower group, this group is made up of the following: Glycerose, otan, erythrose, threose, erythrulose, pectinose, lyxose, ribose, wood sugar, ribulose, xylulose, allose, altrose, semi-lactosi, glucose, gulose, idose, seminose, talose, fructose, psicose, sorbose, tagatose, mannoheptulose, sedoheptulose, octulose, Fucose, rhamnosyl, pectinose, turanose and sialic saccharide.

Those skilled in the art will appreciate that the compound with formula 1 comprises one or more stereocenter. Each stereocenter can be R or S configuration, and this depends on arrangement and the orientation of atom in space. Except as otherwise noted, it should be understood that the compound that this has formula 1 can have any applicable three-dimensional chemical configuration.

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In one embodiment, the present invention is the compound that one has formula 1a :. In another embodiment, the present invention is the compound with formula 1b :. Going back in another embodiment, the present invention is the compound with formula 1c :. In another embodiment, the present invention is the compound with formula 1d :.

In another embodiment, the present invention is the compound with formula 1e :. Going back in another embodiment, the present invention is the compound with formula 1f :.